What is The Mechanism of Inhibition of Normal Blood Formation in Hemoblastosis?
In itself, the suppression of normal hematopoiesis in tumors of hematopoietic cells is the main link in their developmental mechanism.
There is no one mechanism for the suppression of normal blood formation. There may be several such mechanisms. For example, inhibition of erythrocytopoiesis and granulocytopoiesis in subleukemic myelosis may be due to the gradual replacement of the normal microenvironment of hematopoietic tissue due to bone marrow fibrosis induced by leukemic cells. This particular mechanism rarely occurs in other leukemias.
A certain rather specific effect, which can be either stimulation or suppression, is characteristic of a certain form of hemoblastosis, which does not always depend on the stage and characteristics of the process. Specific is the phenomenon in which there is no clear connection between the prevalence of tumor cells in the bone marrow and the inhibition of normal sprouts. Particularly vivid is the picture of the suppression of normal sprouts against the background of a small distribution of leukemic cells in the so-called pre-stages of acute leukemia, when the appearance of separate small groups of blast cells in the bone marrow is accompanied by deep pancytopenia (most often it is the pre-stage of acute erythromyelosis, myeloblastic or myelomonoblast leukemia).