Lesch-Nyana syndrome<\/strong> is a rare inherited disorder.<\/p>\n Hereditary megaloblastic anemia in Rogers syndrome. For the first time in 1969, Rogers and co-authors described a complex hereditary syndrome in an 11-year-old girl \u2014 sugar diabetes, deafness, megaloblastic anemia. This anemia did not respond to therapy with either vitamin B12 or folic acid.<\/p>\n In the same year, other scientists described a similar disease in a 12-year-old girl who had diabetes, deafness and megaloblastic anemia from the age of 3 years. The hemoglobin content was reduced to 60 g \/ l. After ineffectual therapy with vitamin B12, folic acid, pyridoxine, nicotinamide, pantothenate, uridine, thiamine was used in a dose of 20 mg \/ day. At the same time, they managed to achieve an increase in the content of reticulocytes and normalization of erythrocyte and leukocyte indices. Cancel thiamine led to a drop in hemoglobin content. Re-appointment of thiamine was again accompanied by a good therapeutic effect. There were no signs of hypovitaminosis B6 in either the first or the second patient.<\/p>\n Inheritance is recessive, linked to the X chromosome.<\/p>\n The disease causes severe clinical manifestations, including impaired mental development, signs of severe damage to the spinal cord, gout and megaloblastic anemia.<\/p>\n","protected":false},"excerpt":{"rendered":" What is Hereditary Megaloblastic Anemia for Lesch-Nayan Syndrome? Lesch-Nyana syndrome is a rare inherited disorder. Hereditary megaloblastic anemia in Rogers syndrome. For the first time in 1969, Rogers and co-authors described a complex hereditary syndrome<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/posts\/43"}],"collection":[{"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/comments?post=43"}],"version-history":[{"count":1,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/posts\/43\/revisions"}],"predecessor-version":[{"id":44,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/posts\/43\/revisions\/44"}],"wp:attachment":[{"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/media?parent=43"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/categories?post=43"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blood-pressure-meds.com\/blog\/wp-json\/wp\/v2\/tags?post=43"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Causes of Hereditary Megaloblastic Anemia in Lesch-Nayan Syndrome<\/h2>\n
Symptoms of Hereditary Megaloblastic Anemia in Lesch-Nayan Syndrome<\/h2>\n